USA: Octamethylcyclotetrasiloxane (Cyclotetrasiloxane, 2,2,4,4,6,6,8,8-octamethyl-) (D4) Draft Risk Evaluation Under the Toxic Substances Control Act (TSCA) Notice of Availability and Request for Comment
Updated on : 21-09-2025
| The Environmental Protection Agency (EPA or Agency) is announcing the availability of and seeking public comment on a draft risk evaluation under the Toxic Substances Control Act (TSCA) for Octamethylcyclotetrasiloxane (Cyclotetrasiloxane, 2,2,4,4,6,6,8,8- octamethyl-) (D4) (CASRN 556-67-2). The purpose of risk evaluations under TSCA is to determine whether a chemical substance presents an unreasonable risk of injury to health or the environment under the conditions of use (COUs), including unreasonable risk to potentially exposed or susceptible subpopulations identified as relevant to the risk evaluation by EPA, and without consideration of costs or non-risk factors. EPA used the best available science to prepare this draft risk evaluation and to preliminarily determine, based on the weight of scientific evidence, that D4 poses unreasonable risk to human health and the environment driven primarily by certain conditions of use analyzed in the draft risk evaluation.Comments must be received on or before 17 November 2025.90 Federal Register (FR) 44821, 17 September 2025: https://www.govinfo.gov/content/pkg/FR-2025-09-17/html/2025-17967.htmhttps://www.govinfo.gov/content/pkg/FR-2025-09-17/pdf/2025-17967.pdfThis notice and a previous notice notified as G/TBT/N/USA/1775 are identified by Docket Number EPA-HQ-OPPT-2018-0443. The Docket Folder is available on Regulations.gov at https://www.regulations.gov/docket/EPA-HQ-OPPT-2018-0443/document and provides access to primary and supporting documents as well as comments received. Documents are also accessible from Regulations.gov by searching the Docket Number. WTO Members and their stakeholders are asked to submit comments to the USA TBT Enquiry Point by or before 4pmEastern Time on 17 November 2025. Comments received by the USA TBT Enquiry Point from WTO Members and their stakeholders will be shared with EPA and will also be submitted to the Docket on Regulations.gov if received within the comment period. |
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